Pegasus Research Consortium

http://www.youtube.com/watch?v=ugFock3p2xE

This is surprising, I actually dislike Paxman that much - I found myself sitting here thinking, on behalf of the Coca Cola representive, after Paxman said "things need to change", and the rep agree'd - I would have just said:

"People choose to drink it, that's their choice".

Which it is.
Obviously I don't support dastardly corporations either... But the fact remains lol.

The whole idea that somehow the "zero calorie" option is "better" than the sugared one chaps My tail end.  Aspartame (originally a rat poison) as substitute for sugar replaces a natural substance that at least Our bodies recognize and can process (however well in any given Individual) with an unnatural substance that is proven poisonous.  Sounds delightful, eh?  "Better."  Not.

If stevia was used as the sugar substitute, I might say coke was not so bad.  But Aspartame?  Part of Agenda 21 to kill off 90% of Us.

EDIT:  How interesting.  Comments on YT are turned off on this piece.  Why do You think?  Because People will point out the rat poison in the "zero calorie" version?

Quote from: Amaterasu on September 10, 2014, 08:00:18 PM
Aspartame (originally a rat poison) as substitute for sugar replaces a natural substance that at least Our bodies recognize and can process (however well in any given Individual) with an unnatural substance that is proven poisonous.  Sounds delightful, eh?  "Better."  Not.

I agree, our bodies were made to process sugar, not aspartame, but could you please point to some evidence that it was originally a rat poison?

Thanks in advance. :)

PS: now that I have diabetes I have been eating some things with aspartame and other artificial sweeteners, but my youngest sister cannot, aspartame, even in small amounts, is bad for her digestive system.

snopes says it is untrue, about Aspartame being originally a poison. Actually snopes mentions this accusation seems to have been predicated upon  what was originally a "spoof" publication. :))

http://www.snopes.com/media/notnews/antpoison.asp

Probably disabled the comments for that one reason Amy.

I worked behind the bar for 4 years and it was so difficult to keep my mouth shut when eveyone came to order diet. I wanted to educate them, but I couldn't do that at work :(

I seriously cut out the manufactured amino acids when a lady swore blind that she was a new person after removing them from her diet.

I always try to avoid the stuff (although that's a difficult task).
I appalled a shop keeper the once because they had one of those 'meal deals' on, sandwich, crisps n pop for so and so amount.

Now, I did grab the sandwich and the crisps, but I deliberately chose a seperate pop that was Aspartame free (Drench), and the shop keeper 'kindly' reminded me if I swapped the drink I got the 'deal'.... I was surprisingly annoyed, so I went on to inform him that I knew exactly what I was buying and WHY. He looked at me like I had 3 heads lool.

See, they say it's harmless in small amounts, but they fail to highlight the small print which includes.... "It's everywhere in everything".

If memory serves me correctly Aspartame was known to cause brain cancer in a high percentage of lab rats (literally), and it was removed from the market a number of times, but the beloved FDA (is that correct?) Keep rebranding it, and re-selling it.

(Typos I know)

Quote from: rdunk on September 10, 2014, 09:39:46 PM
snopes says it is untrue, about Aspartame being originally a poison. Actually snopes mentions this accusation seems to have been predicated upon  what was originally a "spoof" publication. :))

http://www.snopes.com/media/notnews/antpoison.asp

Snopes is run by two women with zero credentials and is a mouthpiece for money interests.

I have discovered that, whereas I found many articles a few years ago about the rat poison being tasted and discovered to be sweet, and thus was born Aspartame, now those seem to be scrubbed.  What I could find:

http://healthyhealingcy.wordpress.com/tag/rat-poison/  Tagged with rat poison, but no mention of it in the article.

http://www.youtube.com/watch?v=ErngurkB3J0
http://www.youtube.com/watch?v=ErngurkB3J0


http://www.youtube.com/watch?v=OHD9Xqru3NY
http://www.youtube.com/watch?v=OHD9Xqru3NY


http://www.youtube.com/watch?v=aZRo_sAlQ8M
http://www.youtube.com/watch?v=aZRo_sAlQ8M



Guess only fluoride takes the rat poison prize.

Quote from: ArMaP on September 10, 2014, 09:06:54 PM
I agree, our bodies were made to process sugar, not aspartame, but could you please point to some evidence that it was originally a rat poison?

Thanks in advance. :)

PS: now that I have diabetes I have been eating some things with aspartame and other artificial sweeteners, but my youngest sister cannot, aspartame, even in small amounts, is bad for her digestive system.

Look into seeing if You can find stevia there in Portugal.  Not only is it calorie-less, it also supports healthy blood sugar levels.

Quote from: Amaterasu on September 10, 2014, 11:50:23 PM
Look into seeing if You can find stevia there in Portugal.  Not only is it calorie-less, it also supports healthy blood sugar levels.

Thanks, I will look for it. :)

Quote from: Amaterasu on September 10, 2014, 08:00:18 PM
Aspartame (originally a rat poison)

For people that have little knowledge of chemistry  making a connection to rat poison may sound nasty and is certainly a good way to spread fear...

::)

Now I am NOT a fan of aspartame... but just making a statement like that is erroneous at best.


Take Belladonna(or deadly nightshade)  for example. The foliage and berries are extremely toxic, Its long been used as a poison. The Romans used it as a poison, a cosmetic and medicine though

Today many drugs that save lives are made from it, like atropine

The point is that a toxic substance can be (and is commonly) used to create other useful substances that are no longer toxic

So just making a blanket staement like "Its made from rat poison!"  in not the whole picture and more alarmist than factual

BOTOX  used by many women today for cosmetic use. They inject it for getting rid of wrinkles. BOTOX is also used for migraines  yet BOTOX is Botulinum toxin

Botulinum toxin is a protein and neurotoxin produced by the bacterium Clostridium botulinum.[1][2] It is the most acutely lethal toxin known, with an estimated human median lethal dose (LD-50) of 1.3–2.1 ng/kg intravenously or intramuscularly and 10–13 ng/kg when inhaled.[3] Botulinum toxin (BTX) can cause botulism, a serious and life-threatening illness in humans and animals

Aspartame

From Wikipedia, the free encyclopedia



N-(L-?-Aspartyl)-L-phenylalanine,
1-methyl ester
 

Properties

Molecular formula C14H18N2O5
Molar mass 294.30 g mol?1
Density 1.347 g/cm3
Melting point 246–247 °C
Boiling point decomposes
Solubility in water sparingly soluble
Solubility slightly soluble in ethanol
Acidity (pKa) 4.5–6.0[2]

Hazards

NFPA 704

   

Aspartame (APM; /?æsp?rte?m/ or /??sp?rte?m/) is an artificial, non-saccharide sweetener used as a sugar substitute in some foods and beverages. In the European Union, it is codified as E951. Aspartame is a methyl ester of the aspartic acid/phenylalanine dipeptide. It was first sold under the brand name NutraSweet; It was first synthesized in 1965 and the patent expired in 1992.

The safety of aspartame has been the subject of several political and medical controversies, United States congressional hearings and Internet hoaxes[3][4][5] since its initial approval for use in food products by the U.S. Food and Drug Administration (FDA) in 1981.[6]:2 The European Food Safety Authority concluded in its 2013 re-evaluation that aspartame and its breakdown products are safe for human consumption at current levels of exposure,[7] corroborating other medical reviews.[8] However, because its breakdown products include phenylalanine, aspartame must be avoided by people with the genetic condition phenylketonuria (PKU).
Properties and use[edit]


Beta aspartame differs from aspartame based on which carboxyl group binds to phenylalanine


Beta-aspartame differs from aspartame based upon which carboxyl group of aspartate binds to the nitrogen of phenylalanine.
Aspartame, an artificial sweetener, is approximately 200 times sweeter than sucrose, or table sugar. Due to this property, even though aspartame produces four kilocalories of energy per gram when metabolized, the quantity of aspartame needed to produce a sweet taste is so small that its caloric contribution is negligible.[8] The taste of aspartame and other artificial sweeteners differs from that of table sugar in the times of onset and how long the sweetness lasts, though aspartame comes closest to sugar's taste profile among approved artificial sweeteners.[10] The sweetness of aspartame lasts longer than sucrose, so it is often blended with other artificial sweeteners such as acesulfame potassium to produce an overall taste more like sugar.[12] Aspartame can be synthesized from its constituent amino acids, L-phenylalanine and L-aspartate.

Like many other peptides, aspartame may hydrolyze (break down) into its constituent amino acids under conditions of elevated temperature or high pH. This makes aspartame undesirable as a baking sweetener, and prone to degradation in products hosting a high pH, as required for a long shelf life. The stability of aspartame under heating can be improved to some extent by encasing it in fats or in maltodextrin. The stability when dissolved in water depends markedly on pH. At room temperature, it is most stable at pH 4.3, where its half-life is nearly 300 days. At pH 7, however, its half-life is only a few days. Most soft-drinks have a pH between 3 and 5, where aspartame is reasonably stable. In products that may require a longer shelf life, such as syrups for fountain beverages, aspartame is sometimes blended with a more stable sweetener, such as saccharin.[13]

Aspartame's major decomposition products are its cyclic dipeptide (in a 2,5-diketopiperazine, or DKP, form), the de-esterified dipeptide (aspartyl-phenylalanine), and its constituent components, phenylalanine,[14] aspartic acid,[15] and methanol.[16] At 180 °C, aspartame undergoes decomposition to form a diketopiperazine derivative.[17]

In products such as powdered beverages, the amine in aspartame can undergo a Maillard reaction with the aldehyde groups present in certain aroma compounds. The ensuing loss of both flavor and sweetness can be prevented by protecting the aldehyde as an acetal.

Descriptive analyses of solutions containing aspartame report a sweet aftertaste as well as bitter and off-flavor aftertastes


Chemistry[edit]

Aspartame is a methyl ester of the dipeptide of the natural amino acids L-aspartic acid and L-phenylalanine. Under strongly acidic or alkaline conditions, aspartame may generate methanol by hydrolysis. Under more severe conditions, the peptide bonds are also hydrolyzed, resulting in the free amino acids.[9]

While known aspects of synthesis are covered by patents, many details are proprietary.[10] Two approaches to synthesis are used commercially. In the chemical synthesis, the two carboxyl groups of aspartic acid are joined into an anhydride, and the amino group is protected by a compound that will prevent further reactions of that group. Phenylalanine is methylated and combined with the N-protected aspartic anhydride, then the blocking group is removed from aspartic acid by acid hydrolysis. The drawback of this technique is that a byproduct, the bitter tasting ?-form, is produced when the wrong carboxyl group from aspartic acid links to phenylalanine. A process using an enzyme from Bacillus thermoproteolyticus to catalyze the condensation of the chemically altered amino acids will produce high yields without the ?-form byproduct. A variant of this method, which has not been used commercially, uses unmodified aspartic acid, but produces low yields. Methods for directly producing aspartyl-phenylalanine by enzymatic means, followed by chemical methylation, have also been tried, but not scaled for industrial production.[11]

Discovery and approval[edit]

Aspartame was discovered in 1965 by James M. Schlatter, a chemist working for G.D. Searle & Company. Schlatter had synthesized aspartame as an intermediate step in generating a tetrapeptide of the hormone gastrin, for use in assessing an anti-ulcer drug candidate.[19] He accidentally discovered its sweet taste when he licked his finger, which had become contaminated with aspartame, to lift up a piece of paper.[8][20][21]

In 1975, prompted by issues regarding Flagyl and Aldactone, a U.S. FDA task force team reviewed 25 studies submitted by the manufacturer, including 11 on aspartame. The team reported "serious deficiencies in Searle's operations and practices".[6] The FDA sought to authenticate 15 of the submitted studies against the supporting data. In 1979, the Center for Food Safety and Applied Nutrition (CFSAN) concluded, since many problems with the aspartame studies were minor and did not affect the conclusions, the studies could be used to assess aspartame's safety.[6]

In 1980, the FDA convened a Public Board of Inquiry (PBOI) consisting of independent advisors charged with examining the purported relationship between aspartame and brain cancer. The PBOI concluded aspartame does not cause brain damage, but it recommended against approving aspartame at that time, citing unanswered questions about cancer in laboratory rats.[6]:94–96[22]

Citing data from a Japanese study that had not been available to the members of the PBOI,[23] and after seeking advice from an expert panel that found fault with statistical analyses underlying the PBOI's hesitation, yet argued against approval,[6]:53 FDA commissioner Hayes approved aspartame for use in dry goods.[6] In 1983, the FDA further approved aspartame for use in carbonated beverages, and for use in other beverages, baked goods, and confections in 1993. In 1996, the FDA removed all restrictions from aspartame, allowing it to be used in all foods.

Several European Union countries approved aspartame in the 1980s, with EU-wide approval in 1994. The European Commission Scientific Committee on Food reviewed subsequent safety studies and reaffirmed the approval in 2002. The European Food Safety Authority reported in 2006 that the previously established Acceptable daily intake was appropriate, after reviewing yet another set of studies.[24]


United States Pharmacopeia[26]

Safety and approval controversies[edit]

Main article: Aspartame controversy

Aspartame has been found to be safe for human consumption by more than ninety countries worldwide,[27][28] with FDA officials describing aspartame as "one of the most thoroughly tested and studied food additives the agency has ever approved" and its safety as "clear cut",[29] but has been the subject of several controversies, hoaxes[3] and health scares.[30]

Initially aspartame was approved by the U.S. Food and Drug Administration (FDA) in 1974, however, problems with Searle's safety testing program, including testing of aspartame, were discovered subsequently. The approval was rescinded the following year, but after outside reviews of the problematic tests and additional testing, final approval was granted in 1981. Because allegations of conflicts of interest marred the FDA's approval of aspartame,[6][31][32] the U.S. Government Accountability Office reviewed the actions of involved officials in 1986 and the approval process in 1987; neither the allegations of conflict of interest nor problems in the final approval process were substantiated.[6][33]

In addition, the Centers for Disease Control investigated in 1984 and was unable to find any significant epidemiological associations to serious risk or harm.[34]

Since December 1998, a widely circulated email hoax cited aspartame as the cause of numerous diseases.[35]

The weight of existing scientific evidence indicates that aspartame is safe at current levels of consumption as a non-nutritive sweetener.[8] Reviews conducted by regulatory agencies decades after aspartame was first approved have supported its continued availability.[36] The consumer advocacy group the Center for Science in the Public Interest continues to promote the position that aspartame is not safe.[37]

Safety and health effects[edit]

The safety of aspartame has been studied extensively since its discovery with research that includes animal studies, clinical and epidemiological research, and postmarketing surveillance,[38] with aspartame being one of the most rigorously tested food ingredients to date.[39] Peer-reviewed comprehensive review articles and independent reviews by governmental regulatory bodies have analyzed the published research on the safety of aspartame and have found aspartame is safe for consumption at current levels.[8][38][40][41] Aspartame has been deemed safe for human consumption by over 100 regulatory agencies in their respective countries,[41] including the UK Food Standards Agency,[42] the European Food Safety Authority (EFSA)[43] and Health Canada.[44]

Good detail info sky! I suppose some skeptics might suspect/say that Aspartame probably wrote the wiki report!??

I still think Equal/Aspartame is the best tasting artificial sweetener! But, I do still believe that nothing beats the sweetness taste of good ole sugar!!!!!!!!!!!!!!!!!!!!!!!!! :))

yeah rdunk
it always amazes me how people will shoot off their mouths  and repeat things without checking the facts first   ::)

Quote from: rdunk on September 11, 2014, 03:57:03 AMBut, I do still believe that nothing beats the sweetness taste of good ole sugar!!!!!!!!!!!!!!!!!!!!!!!!! :))

Are you aware that COCKROACHES will not touch refined sugar (or margerine)?

"food" for thought

;D

::)

Quote from: zorgon on September 11, 2014, 09:51:49 PM
Are you aware that COCKROACHES will not touch refined sugar (or margerine)?

Could you please point to some evidence that what you just wrote is true? :)

Thanks in advance.

I have already looked it up earlier ArMaP, and it is mixed. I didn't save anything, but apparently some cockroaches have, by fairly quick evolutionary means, developed a "bitter taste" for anything sweet. This came about as a result of exterminators using sweetness to hide the bitter taste of poison prepared and presented for killing cockroaches. So, over time "some" cockroaches in "some" countries now will not eat anything that is sweet. But then, there are other cockroaches in other countries that still will eat sweetness.

The article I read said that these cockroaches now sample a potential food first with some body part/antenna, that senses for taste - if it is bitter, then they do not eat it.

Thanks, rdunk, that makes sense. :)

Aspartame is banned in some countries because it causes dementia in many people.

Quote from: Pimander on September 12, 2014, 12:38:35 PM
Aspartame is banned in some countries because it causes dementia in many people.

I know that I'm sounding like a broken record, but could you please point to some evidence of that?

Thanks in advance. :)

Quote from: ArMaP on September 12, 2014, 02:01:20 PM
I know that I'm sounding like a broken record, but could you please point to some evidence of that?

Thanks in advance. :)

http://articles.mercola.com/sites/articles/archive/2014/06/26/aspartame-methanol-alzheimers.aspx

    Year Published: 1970
    Full Reference: Brain Damage in Infant Mice Following Oral Intake of Glutamate, Aspartate, or Cysteine; Nature 1970;227-609-610
    Funded By: Washington University
    Conclusion/Findings: Irreversible degenerative changes and acute neuronal necrosis
    Hyperlink to Study http://www.nature.com/nature/journal/v227/n5258/pdf/227609b0.pdf
    Year Published: 2008
    Full Reference: Direct and Indirect Cellular Effects of Aspartame on the Brain. European Journal of Clinical Nutrition (2008) 62, 451-462; P. Humphries, E. Pretorius, and H. Naude
    Funded By: Not known
    Conclusion/Findings: Excessive aspartame ingestion might cause certain mental disorders, as well as compromised learning and emotional functioning
    Hyperlink to Study: http://www.newmediaexplorer.org/sepp/aspartamebrain.pdf
    Year Published: 2007
    Full Reference: Life-Span Exposure to Low Doses of Aspartame Beginning During Prenatal Life Increases Cancer Effects in Rats, Morando Soffritti, Fiorella Belpoggi, Eva Tibaldi, Davide Degli Esposti, Michelina Lauriola; Environmental Health Perspectives, 115(9) Sep 2007; 115:1293-1297. doi:10.1289/ehp.10271.
    Funded By: Not known
    Conclusion/Findings: Carcinogenicity proven a second time; with effects increased when exposure to aspartame begins during fetal life.
    Hyperlink to Study: http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info:doi/10.1289/ehp.10271
    Year Published: 1984
    Full Reference: Effects of Aspartame and Glucose on Rat Brain Amino Acids and Serotonin. Yokogoshi H, Roberst CH, Caballero B, Wurtman RJ. American Journal of clinical Nutrition. 1984 July, 40(1):1-7
    Funded By: MIT
    Conclusion/Findings: High aspartame doses can generate major neurochemical changes in rats, especially when consumed along with carbohydrate-containing foods
    Hyperlink to Study: http://www.ncbi.nlm.nih.gov/pubmed/6204522
    Year Published: 1984
    Full Reference: Revelance of Animal Studies to Human Safety. Olney, JW. Neurobehavioral Toxicology and Teratology. 1984; 6:455-462
    Funded By: MIT
    Conclusion/Findings: Excitotoxins, as used in foods today, may produce blood elevations high enough to cause damage to the nervous system of young children, damage which is not detectable at the time of occurrence but which may give rise to subtle disturbances in neuroendocrine function in adolescence and/or adulthood.
    Hyperlink to Study: http://www.ncbi.nlm.nih.gov/pubmed/6152304
    Year Published: 1996
    Full Reference: Increasing Brain Tumor Rates: Is There a Link to Aspartame? Olney JW, Farber NB, Spitznagel E, Robins LN. Journal of Neuropatholgy & Experimental Neurology. 1996 Nov; 55(11):1115-23
    Funded By: NIH
    Conclusion/Findings: Brain tumor incidence in the US implicates the introduction of aspartame into the American diet.
    Hyperlink to Study: http://www.ncbi.nlm.nih.gov/pubmed/8939194
    Year Published: 2000
    Full Reference: Glutamate and Aspartate Impair Memory Retention and Damage Hypothalamic Neurons in Adult Mice. Cheol Hyoung Park, Se Hoon Coi, et al. Toxicology Letters, Vol. 115, Issue 2, May 19, 2000, pp. 117-125
    Funded By: Not known
    Conclusion/Findings: Found that aspartate shortens the memory response, impairs memory retention and damages hypothalamic neurons in mice
    Hyperlink to Study: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCR-408BJC1-4&_user=10&_coverDate=05%2F19%2F2000&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view
    =c&_searchStrId=1456058577&
    _rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=395a2fc9d4ef0ffceeea475146341607
    &searchtype=a
    Year Published: 2002
    Full Reference: Effect of Aspartame on N-Methyl-D Asparate Sensitive L-(311) Glutamate Binding Sites in Rat Brain Synpatic Membranes, AV Glushakov, DM Dennis, et al. Molecular Psychiatry, 2002, Vol. 7, No. 4, pp. 359-367.
    Funded By: University of Florida
    Conclusion/Findings: Shows that aspartate has a role in causing mental retardation, but the mechanism by which it does that is still unknown.
    Hyperlink to Study: http://www.nature.com/mp/journal/v7/n4/full/4000976a.html
    Year Published: 2006
    Full Reference: The Effect of Aspartame Metabolites on Human Erythrocyte Membrane Acetylcholinesterase Activity. Stylianos Tsakiris, Aglaia Giannoulia-Karantana, et al., Pharmacological Research, Volv. 53, Issue 1, Jan. 2006. pp. 1-5.
    Funded By: Not known
    Conclusion/Findings: Found that high concentrations of aspartame can cause neurological symptoms, including memory and learning problems.
    Hyperlink to Study: http://www.ncbi.nlm.nih.gov/pubmed/16129618
    Year Published: 2008
    Full Reference: Direct and Indirect Cellular Effects of Aspartame on the Brain, P Humphries, E Pretorius and H Naude, European Journal of Clinical Nutrition , 2008, 62, 451-462
    Funded By: Not known
    Conclusion/Findings: Asserts that excessive aspartame ingestion might be involved in the pathogenesis of certain mental disorders (DSM-IV-TR 2000) and also in compromised learning and emotional functioning.
    Hyperlink to Study: http://www.nature.com/ejcn/journal/v62/n4/abs/1602866a.html
    Year Published: 1986
    Full Reference: Evaluation of Reactions to Food Additives: The Aspartame Experience. MK Bradstock, MK Serdula, JS Marks, RJ Barnard, Nt Crane, PL Remington and FL Trowbridge. The American Journal of Clinical Nutrition. Vol. 43, pp. 464-469, 1986
    Funded By: Not known
    Conclusion/Findings: Identified some case reports in which the symptoms may be attributable to aspartame in commonly-consumed amounts. Headache, mood alterations (anxiety, agitation, irritability, or depression), insomnia, dizziness, and fatigue were the most frequently reported symptoms, with one case of a child in a double-blind test who became hyperactive after consuming products with aspartame.
    Hyperlink to Study: http://www.ajcn.org/cgi/reprint/43/3/464 and http://www.ajcn.org/cgi/content/abstract/43/3/464
    Year Published: 1990
    Full Reference: Aspartame: Clinical Update, Potenza DP, el-Mallakh RS, Connecticut Medicine, 1990 Apr;54(4):235-6.
    Funded By: Not known
    Conclusion/Findings: Raises concern that so many reports of headaches, seizures, blindness, and cognitive and behavioral changes with long-term, high-dose aspartame have been reported that health officials need to be concerned.
    Hyperlink to Study: http://www.ncbi.nlm.nih.gov/pubmed/2667892
    Year Published: 1993
    Full Reference: Adverse Reactions to Aspartame: Double-Blind Challenge in Patients from a Vulnerable Population. Ralph G. Walton, Robert Hudak, Ruth J. Green-Waite. Psychiatry. July 1, 1993. Vol. 34, Issue 1, pp. 13-17.
    Funded By: Dept. of Psychiatry Northeastern Ohio,Universities  College of Medicine and University Hospital of Cleveland
    Conclusion/Findings: Found that individuals with mood disorders are particularly sensitive to this artificial sweetener and its use in this population should be discouraged. In the clinical study, the project was halted by the Institutional Review Board after a total of 13 individuals had completed the study because of the severity of reactions within the group of patients with a history of depression
    Hyperlink to Study: http://www.biologicalpsychiatryjournal.com/article/0006-3223%2893%2990251-8/abstract
    Year Published: 1986
    Full Reference: Seizure and Mania After High Intake of Aspartame
    Funded By: Jamestown General Hospital, Jamestown, New York
    Conclusion/Findings: Case report of a woman who drank in excessive of 1 gallon per day of iced tea sweetened with aspartame, resulting in manic episode and seizure that led to hospitalization.
    Hyperlink to Study: http://psy.psychiatryonline.org/cgi/pdf_extract/27/3/218
    Year Published: 1991
    Full Reference: Effect of Aspartame and Protein, Administered in Phenylalanine-Equivalent Doses, on Plasma Neutral Amino Acids, Aspartate, Insulin and Glucose in Man, Svend E. Moller; Pharmacology & Toxicology, Vol. 68, Issue 5, pp. 408-412.
    Funded By: Clinical Research Laboratory, Denmark
    Conclusion/Findings: The study showed that the intake of aspartame in a not unrealistically high dose produced a marked and persistent increase of the availability of Phe to the brain, which was not observed after protein intake. The study indicated, furthermore, that Phe was cleared faster from the plasma after consumption of protein compared with aspartame.
    Hyperlink to Study: http://www3.interscience.wiley.com/journal/122214234/abstract
    Year Published: 1994
    Full Reference: Effects of Diets High in Sucrose or Aspartame on the Behavior and Cognitive Performance of Children. Mark L. Wolraich, Scott D. Lingren, et al. New England Journal of Medicine, Feb. 3, 1994; pp. 330:301-307
    Funded By: Not known
    Conclusion/Findings: Reported that it is possible that there are some children who respond adversely to sugar or aspartame.
    Hyperlink to Study: http://www.nejm.org/doi/full/10.1056/NEJM199402033300501#articleResults
    Year Published: 1985
    Full Reference: Loss of Intellectual Function in Children with Phenylketonuria After Relaxation of Dietary Phenylalanine Restriction, Margretta R. Seashore, Estelle Friedman, Robert A. Novelly P, Vijaya Bapat MD. Pediatrics vol. 75, No. 2, Feb. 1985, pp. 226-232
    Funded By: Not known
    Conclusion/Findings: Shows decrease in intellectual function in children with PKU who have phenylalnine introduced into their diets.
    Hyperlink to Study: http://pediatrics.aappublications.org/cgi/content/abstract/75/2/226
    Year Published: 1987
    Full Reference: Aspartame Effects on Brain Serotonin, RI Wurtman, Letter in American Journal of Clinical Nutrition, 1987 April; 45(4):799-803
    Funded By: MIT
    Conclusion/Findings: Argues that using rodents to disprove aspartame's harm to humans is not relevant, and that it reacts more negatively in humans than in mice
    Hyperlink to Study: http://www.ajcn.org/cgi/reprint/45/4/799.pdf
    Year Published: 1986
    Full Reference: Acute Effects of Oral or Parenteral Aspartame on Catecholamine Metabolism in Various Regions of Rat Brain, Hidehiko Yokogoshi and Richard J. Wurtman, The Journal of Nutrition, November 1986
    Funded By: MIT
    Conclusion/Findings: Found higher plasma tyrosine and phenylalanine ratios and other effects on the brain.
    Hyperlink to Study: http://jn.nutrition.org/cgi/content/abstract/116/3/356
    Year Published: 1992
    Full Reference: Aspartame Exacerbates EEG Spike Wave Discharge in Children with Generalized Absence Epilepsy, PR Camfield, CS Camfield, JM Dooley, et al;
    Funded By: Ontario Ministry of Health
    Conclusion/Findings: Neurology 1992:42:1000
    Hyperlink to Study: http://www.neurology.org/cgi/content/abstract/42/5/1000
    Year Published: 1993
    Full Reference: The Effect of Food Chemicals on Cell Aging of Human Diploid Cells in Vitro Culture, Kasamaki A and Urasawa S, The Journal of Toxicological Sciences, 1993 Aug; 18(3):143-53
    Funded By: Toxicological Sciences, 1993 Aug; 18(3):143-53. Sapporo
    Conclusion/Findings: Showed aging of cells when treated with aspartame.
    Hyperlink to Study: http://www.ncbi.nlm.nih.gov/pubmed/8246307
    Year Published: 1994
    Full Reference: Neuropharmacological Evaltuation of Movement Disorders that are Adverse Reactions to Specific Foods Including Aspartame, John W. Gerrard, J Steven Richardson and Jeffrey Donat; International Journal of Neuroscience, 1994, Vol. 76, No. 1-2, pp. 61-69
    Funded By: University of Saskatchewan, Canada
    Conclusion/Findings: Shows that in susceptible individuals, certain foods or additives, including aspartame, can trigger movement disorders through an action on dopamine and other neurotransmitter pathways in the brain.
    Hyperlink to Study: http://informahealthcare.com/doi/abs/10.3109/00207459408985992
    Year Published: 1995
    Full Reference: Effects of Aspartame on 45 CA Influx and LDH Leakage from Nerve Cells in Culture, Sonnewald U, Unsgard G, Petersen SB; Neuropharmacology and Neurotoxicology, 1995, Vol. 6, Issue 2
    Funded By: Research Council of Norway
    Conclusion/Findings: Showed signs of severe cell damage and other neurological events with aspartame.
    Hyperlink to Study: http://journals.lww.com/neuroreport/Abstract/1995/01000/Effects_of_aspartame_on_45Ca_influx_and_LDH.23.aspx
    Year Published: 1996
    Full Reference: Increasing Brain Tumor Rates: Is There A Link to Aspartame? JW Olney, Nuri B Farber, et al.; Journal of Neuropathology & Experimental Neurology, Nov. 1996, Vol. 55, Issue 11
    Funded By: NIH
    Conclusion/Findings: Evidence implicates aspartame as a causative agent of high incidence of brain tumors in aspartame-fed rats.
    Hyperlink to Study: http://journals.lww.com/jneuropath/Abstract/1996/11000/Increasing_Brain_Tumor_Rates__Is_There_a_Link_to.2.aspx
    Year Published: 1998
    Full Reference: Formaldehyde Derived from Dietary Aspartame Binds to Tissues Components in Vivo, C. Trocho, R. Pardo, I. Rafecas, et al
    Funded By: University of Barcelona, Spain
    Conclusion/Findings: Showed that aspartame consumption may constitute a hazard because of its contribution to the formation of formaldehyde adducts.
    Hyperlink to Study: http://www.wnho.net/formaldehyde_from_aspartame.pdf

Thanks, Sinny and Pimander, but that only confirms half of what was said, that Aspartame causes dementia in many people, I didn't see any confirmation of the first half, that Aspartame is banned in some countries because of that. :)

how's this ArMaP


http://articles.mercola.com/sites/articles/archive/2014/06/26/aspartame-methanol-alzheimers.aspx


Supporting Evidence for Aspartame-Alzheimer's Link Emerges


June 26, 2014 | 257,697 views
| Available in EspañolDisponible en Español

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Visit the Mercola Video Library
By Dr. Mercola

can't  get the you tube to copy here..sorry

Most public health agencies and nutritionists in the United States still recommend no- or low-calorie artificial sweeteners as an acceptable, and even preferred, alternative to sugar. This flawed advice can have very serious repercussions for those who follow it.

Artificial sweeteners of all kinds have been found to wreak havoc with your health in a number of different ways. Aspartame, which is perhaps the worst of the bunch, has a long list of studies indicating its harmful effects, ranging from brain damage to pre-term delivery.

Aspartame is also the number one source of side effect complaints to the US Food and Drug Administration (FDA), with over 10,000 complaints filed and over 91 documented symptoms related to its consumption.

Most recently, studies are also starting to confirm lingering suspicions that artificial sweeteners like aspartame may play a role in the development of Alzheimer's disease, a serious form of dementia that is now thought to kill over half a million Americans each year.

The key mechanism of harm appears to be methanol toxicity—a much-ignored problem associated with aspartame in particular.

In a previous interview, toxicology expert Dr. Woodrow Monte (author of the book While Science Sleeps: A Sweetener Kills1), explained the links between aspartame and methanol toxicity and the formation of formaldehyde. In light of the latest research, this interview is more relevant than ever, which is why I included it again.

Methanol Toxicity Leads to Persistent Alzheimer's Symptoms


A recently published two-part paper2, 3 highlights what Dr. Monte has been saying for many years now—that methanol acts differently in animals and humans. In this case, the researchers also discovered changes in effect between mice and rhesus monkeys.

Methanol-fed mice presented with partial "Alzheimer's disease-like symptoms," while rhesus monkeys fed a 3% methanol solution developed persistent pathological changes related to the development of Alzheimer's. According to the authors:


"A recently established link between formaldehyde, a methanol metabolite, and Alzheimer's disease (AD) pathology has provided a new impetus to investigate the chronic effects of methanol exposure.

This paper expands this investigation to the non-human primate, rhesus macaque... [M]ethanol feeding led to persistent memory decline in the monkeys that lasted 6 months beyond the feeding regimen...

Most notably, the presence of amyloid plaque formations in the monkeys highlighted a marked difference in animal systems used in AD investigations, suggesting that the innate defenses in mice against methanol toxicity may have limited previous investigations into AD pathology.

Nonetheless, these findings support a growing body of evidence that links methanol and its metabolite formaldehyde to AD pathology." [Emphasis mine]

The Link Between Aspartame and Methanol Toxicity


The artificial sweetener industry (and makers of artificially sweetened products) has fervently claimed that aspartame is harmless, and that there's "no biological explanation" for the health problems reported by so many after consuming aspartame.

But as explained by Dr. Monte, there is indeed a biological and scientific explanation for aspartame's pathway of harm, and as the latest research suggests, it's related to the effects of methanol and formaldehyde, both of which are extremely toxic.

Aspartame is primarily made up of aspartic acid and phenylalanine—the latter of which has been synthetically modified to carry a methyl group. This is what provides the majority of the sweetness. That phenylalanine methyl bond, called a methyl ester, is very weak, allowing the methyl group on the phenylalanine to easily break off and form methanol.

You may have heard the claim that aspartame is harmless because methanol is also found in fruits and vegetables. However, in these whole foods the methanol is firmly bonded to pectin, which allows it to be safely passed through your digestive tract. This is not the case for the methanol created by aspartame. There, it's not bonded to anything that can help eliminate it from your body. That's problem number one...

Problem number two relates to the fact that humans are the only mammals who are NOT equipped with a protective biological mechanism that breaks down methanol into harmless formic acid. This is why animal testing of aspartame does not fully apply to humans.

According to Dr. Monte, the fact that methyl alcohol is metabolized differently in humans compared to other animals has been known since 1940. And according to the featured paper, rhesus monkeys do not appear to have the same defenses against methanol toxicity as mice do. This basically negates much of the animal research that has been used to "prove" aspartame's safety.

Methanol Acts as a Trojan Horse in Your Body


As explained by Dr. Monte, in humans, methanol ends up acting as a Trojan horse, allowing toxic formaldehyde to wreak havoc in some of your most sensitive areas, such as your brain. Here's how it works: both animals and humans have small structures called peroxisomes in each cell. There are a couple of hundred in every cell of your body, which are designed to detoxify a variety of chemicals. Peroxisome contains catalase, which help detoxify methanol.

Your cells also contain alcohol dehydrogenase (ADH), which converts methanol to formaldehyde. Other chemicals in the peroxisome in turn convert the formaldehyde to formic acid, which is harmless—but this last step occurs only in animals. Human peroxisomes cannot convert the toxic formaldehyde into harmless formic acid.

Certain locations in your body, particularly in the lining of your blood vessels, and in your brain, are loaded with ADH that converts methanol to formaldehyde. But since there's no catalase present, the formaldehyde does not get converted into harmless formic acid. As a result, the formaldehyde is free to do enormous amounts of damage in your tissues.

Symptoms of methanol poisoning include: headaches, ear buzzing, dizziness, nausea, gastrointestinal disturbances, weakness, vertigo, chills, memory lapses, numbness, and shooting pains in the extremities, behavioral disturbances, and neuritis. The most well known problems from methanol poisoning are vision problems including misty vision, progressive contraction of visual fields, blurring of vision, obscuration of vision, retinal damage, and blindness. Formaldehyde, in turn, is a known carcinogen that causes retinal damage, interferes with DNA replication, and may cause birth defects.

Processed Foods Are Also High in Methanol


As I've discussed in previous articles, processed foods should be avoided as a proactive Alzheimer's prevention strategy. In his book, Grain Brain, neurologist Dr. Perlmutter reveals how the toxic activity of sugar and carbohydrates in your diet promote Alzheimer's disease. But we can also add methanol to the list of reasons for avoiding processed foods. Not only do many processed foods contain artificial sweeteners, but when fruits and vegetables are canned, for example, the methanol becomes liberated from the pectin.

At room temperature, it only takes one month for 10 percent of the methanol to be released. After about six months, virtually all of the methanol is liberated. Dr. Monte is convinced that methanol and the subsequent conversion to formaldehyde from certain processed foods (see listing below), as well as all foods containing aspartame, are a major culprit in a variety of diseases, especially multiple sclerosis (MS).

Again, methanol can slip through your blood brain barrier, and your brain is one of the areas where you find alcohol dehydrogenase, which converts methyl alcohol to formaldehyde. This causes the destruction of myelin basic protein, which is one of the triggers for MS. Demyelination also plays a role in the development of Alzheimer's and several other brain-related diseases. According to Dr. Monte:


"We know that methyl alcohol is known to be a demyelinating agent... [T]he symptoms associated with the demyelination... are identical between multiple sclerosis, and methanol poisoning, and people who consume aspartame."

He believes many diseases can be prevented if we start avoiding methanol from all sources, and he even offers a methanol-free diet on his website.4 Items to avoid include:

Cigarettes 
Cigarettes  Tomato sauces, unless first simmered at least 3 hours, no lid on pan 
Diet foods and drinks with aspartame  Smoked food of any kind, particularly fish and meat 
Fruit and vegetable products and their juices in bottles, cans, or pouches  Chewing gum, as most chewing gum in the USA contains aspartame 
Jellies, jams, and marmalades not made fresh and kept refrigerated  Slivovitz and other fruit schnapps 
Black currant and tomato juice products, fresh or processed  Overly ripe or near rotting fruits or vegetables 

The Neurotoxic Properties of Splenda


Another popular artificial sweetener is sucralose, sold under the brand name Splenda. Sucralose is a synthetic chemical created in a five-step patented process, in which three chlorine molecules are added to one sucrose (sugar) molecule. Some will argue that natural foods also contain chloride, which is true. However, in natural foods, the chloride is connected with ionic bonds that easily dissociate when ingested. In Splenda, they're in a covalent bond that does not dissociate.

And, since your body has no enzymes to break down this covalently bound chloride, harm can ensue... The reason why your body has no enzymes for this task is because, in nature, there are NO covalent chloride bonds to organic compounds—they only exist in synthetic, man-made form. Aside from Splenda, other examples of synthetic covalently bound chloride compounds include DDT, PCBs, and Agent Orange.

Previous research indicates that about 15 percent of sucralose is absorbed into your digestive system, and ultimately stored in your body fat. A 2008 animal study5 found that Splenda reduced the amount of beneficial intestinal bacteria by 50 percent, increased the intestinal pH level, and affected a glycoprotein that can have crucial health effects, particularly if you're on certain medications.

More recent research6 detailing Splenda's oxidative effects, suggests the sweetener may have neurotoxic properties, which doesn't surprise me in the least. The researchers, who assessed the effects of sucralose on water fleas, concluded that: "exposure to sucralose may induce neurological and oxidative mechanisms with potentially important consequences for animal behavior and physiology." As reported by GreenMedInfo.com:7


"Like so many novel patented chemicals released onto the market without adequate pre-approval safety studies, we do not know if this preliminary toxicological research will be applicable to human exposures. In fact, there are only 318 study citations on this chemical in existence since it first began to be researched in the 70's. This most recent study is the first in existence to look at its effect on the enzyme acetylcholinesterase, which is found in all animals.

This information deficit is all the more remarkable when you consider there are over 7,000 published studies in existence on either turmeric or its primary polyphenol curcumin, which is still not readily administered by the conventional medical establishment mostly due to 'safety concerns,' despite what the voluminous positive data on its relevance to over 600 health conditions indicates."

FDA Approval Means Little When It Comes to Ascertaining Safety


As previously noted by Dr. Janet Hull,8 many tend to excuse the negative health effects of aspartame simply because it has received the stamp of approval by the FDA. But as discussed in her article, "Abusing the FDA Approval Process,"9 the FDA requires that the industry do its own research, and actually places the burden of proof on the company making the product. Rarely is the industry research reviewed by independent researchers. Should you still be confused on this issue, thinking that the buck somehow stops at the FDA, FDA spokesman Theresa Eisenman recently clarified who is ultimately responsible for making sure a food product is safe, stating that:10 "Manufacturers are responsible for ensuring that their food products are safe and lawful..."

But what company would really make a serious effort to find problems with the very products they want to capitalize on? Despite this illogical premise, the FDA trusts corporations to be honest in their research and evaluations. How likely do you think it is that this "honor system" will actually ensure that each product released to market is safe?

When it comes to artificial sweeteners, aspartame in particular, there's no doubt in my mind that the system has protected industry profits at consumers' expense. And we've not seen the last of it. Despite mounting evidence showing that artificial sweeteners as a group have adverse health effects, the FDA has just approved yet another artificial sweetener called Advantame,11, 12, 13 concocted from a combination of aspartame and vanillin, an artificial vanilla flavor.

Being 20,000 times sweeter than refined sugar, Advantame is the sweetest artificial sweetener so far. To put this into perspective, aspartame, sucralose, and saccharine range from 200 to 700 times sweeter than sugar. Also, as reported by the LA Times:14


"Like aspartame, advantame contains phenylalanine, which is metabolized with difficulty by people with a rare genetic disorder, phenylketonuria. But because of its intense sweetness, advantame would be used at much lower volumes than is asparatame. As a result, the FDA has declared that it can be safely consumed by those with phenylketonuria."

Having a Hard Time Giving Up Artificial Sweeteners?


When you consume artificial sweeteners, your brain actually craves more calories because your body receives no satisfaction on a cellular level by the sugar imposter. This can contribute to not only overeating and weight gain, but also an addiction to artificial sweeteners. To break free, I recommend addressing any emotional component of your food cravings using a tool such as the Emotional Freedom Technique (EFT). A version of EFT specifically geared toward combating sugar cravings is called Turbo Tapping. The video below with EFT practitioner Julie Schiffman also demonstrates how to use EFT to fight food cravings of all kinds.


http://www.youtube.com/watch?v=L92oOPJlfyg

If you still have cravings after trying EFT or Turbo Tapping, you may need to make some changes to your diet. My free nutrition plan can help you do this in a step-by-step fashion. As for safer sweetener options, you could use stevia or Luo Han, both of which are safe natural sweeteners. That said, if you struggle with high blood pressure, high cholesterol, diabetes or extra weight, then you have insulin sensitivity issues and would likely benefit from avoiding ALL sweeteners.

Last but not least, if you experience side effects from aspartame or any other artificial sweetener, please report it to the FDA (if you live in the United States) without delay. It's easy to make a report — just go to the FDA Consumer Complaint Coordinator page, find the phone number for your state, and make a call reporting your reaction

Thanks, sky otter, but that's the article for which Sinny posted the link.  :)

opps    :-[

I had several pages open and copied the wrong one.. but it all seems to go back to this one man Dr. Joseph Mercola



http://www.wnho.net/evidence_for_aspartame_alzheimers_link.htm


SUPPORTING EVIDENCE FOR ASPARTAME-ALZHEIMER'S LINK EMERGES
By Dr. Betty Martini, D.Hum.
Mission Possible International
9270 River Club Parkway
Duluth, Georgia 30097
Telephone: 770-242-2599
E-Mail: BettyM19@mindspring.com
Web Site: http://www.mpwhi.com


Posted: 10 July 2014


The Alzheimer's link has been there for 30 years, and having spoken to informants and researchers for at least a quarter of a century nobody doubts the issue. While some may be hearsay, I hear what they are saying. There is an old saying, "Where there is smoke there is fire". In this case it's a blazing conflagration.

Dr. H. J. Roberts in his medical text: "Aspartame Disease, An Ignored Epidemic" - http://www.sunsetpress.com, list the following reactors who were less than 60: page 561


•An 18 year old man experienced severe confusion when he drank two liters of an aspartame beverage daily.

•A woman was concerned about her husband who consumed 2-3 two liter bottles of diet drinks daily. She stated, "He was always complaining to me that he thought he was getting senile because he couldn't remember anything."

•The memory of a 59 year old man deteriorated while consuming three liters of diet cola daily. His physician-son expressed concern about "early Alzheimer's Disease"

•A 40 year old professional speaker experienced " disorientation and couldn't remember things" within minutes to an hour whenever she drank an aspartame cola.

•A housewife in her 50's described her reactions after seeing an article about my research on aspartame disease in the Saturday Evening Post.
•She also cited other friends who had comparable memory loss and headache, including a married couple (both teachers). "


I've been taking these types of histories for almost a quarter of a century. Indeed memory loss is so prevalent its number 9 on the FDA list of 92 documented symptoms from four types of seizures to coma and death. http://www.mpwhi.com/92_aspartame_symptoms.pdf Another case history in Dr. Roberts text, page 563 is typical of most cases:
"I was drinking an aspartame soda in large amounts since it came out in the summer of 1983. For the last six or seven months, I found I was losing my presence of mind. My short term memory was bad. I did stupid things due to lack of alertness, and my eyes were very sensitive to sunlight. Does this sound like an aspartame problem? I am age 70, 160 lbs, in good health, and had no problem at all until this came about. "

Calls still come in from hospices where nurses tell me they don't understand why they are receiving patients with Alzheimer's at the age of 25 or 30! Michael Fox, a diet Pepsi spokesman, said about his case of Parkinson's, "I don't understand why I was diagnosed with an old age disease, at age 30"! Aspartame knows no age. Damage to the mitochondria or powerhouse of the cell by aspartame makes you grow old. Dr. James Bowen who is an aspartame victim with ALS said after 6 weeks on aspartame his black hair turned white.

Years ago I received an email from someone named Craig who said he was told by a Pepsi employee to not use aspartame because the National Soft Drink Association (now American Beverage) had completed a ten year study on aspartame. It proved that aspartame causes birth defects, blindness and Alzheimer's! What was most interesting about this is I met a woman who said she worked for NSDA and aspartame was safe. When I told her about the 10 year study she said, "There is no way you could have gotten those studies." If that wasn't an admission I don't know what is. She got so upset someone had to get her a glass of water and help her to her car.

During the Olympics here in Atlanta we met a lady who was dating someone in the Monsanto family. She said, "Why do they tell their friends not to use aspartame because it causes Alzheimer's?" I told her to ask the question gives her the answer. In fact, a friend who was once married to a man who worked for Monsanto said her husband was told "do not use aspartame, we don't want sick employees, do not bring it into your home or allow your family to use it. It is a poison." Confession is good for the soul! We tried to get him to give us an affidavit but he said he had signed an agreement not to give out this information. Since it was many years ago we didn't think it mattered, but he refused. He also said to show you the relationship of Monsanto with FDA that he had actually been sent there by Monsanto to work there awhile. Then he was sent to G. D. Searle. That's when he quit after he was shown how they do the studies. The cover-up was a no-brainer.

Some years ago my husband and I went through St. Louis to get to Albuquerque. We went there to get information to the pilots at the Air Force Base. We gave out flyers in the airport and a young man said, "my mother rents to a physician, and he told us that aspartame causes Alzheimer's, and the physicians in St. Louis were told if they told anyone they would be sued."

This dementia and memory loss by aspartame victims can be dangerous. That's why we have Mission Possible Aviation and get Dr. Russell Blaylock's pilot alert to pilots and crew everywhere. http://www.mpwhi.com/pilot_aspartame_alert.htm Dr. Roberts once said he was talking to someone in air traffic control, and the man was drinking a Diet Coke, didn't know who he was or where he was. Mission Possible Aviation was set-up after Cliff Evans crashed his plane in a tree and he lived to tell about it. He said, "Dumb I'm not, but I couldn't make a decision on aspartame." When victims get off aspartame brain fog is usually the first to go.

Dr. Roberts wrote a book called "Defense Against Alzheimer's Disease", http://www.sunsentpress.com and says aspartame is escalating Alzheimer's Disease. Most people are probably interested in how aspartame triggers this disease. In his text he gives the underlying mechanisms. He says, "The confusion and memory loss induced by aspartame and its components probably reflect multiple mechanisms:

"Unchecked flooding of the brain by L-phenylalanine, L-aspartic acid, and their L-iso or D-stereoisomers.

The toxic effects of free methyl alcohol.

The toxic effects of free methyl alcohol.

Metabolic breakdown products of aspartame formed during heating and prolonged storage.

Binding of excitatory amino acids to the membranes of brain cells.

Dysfunction induced by amino acid-derived neurotransmitters and related substances.

Induced or aggravated hypoglycemia from excess insulin secretion.

Interference with the degradation of amyloid B-protein, which then may accumulate - perhaps involving proteolysis by insulin-degrading enzyme (Vekrellis 2000).

A marked increase of beta endorphins (Melchior 1991)"

Russell Blaylock, M.D., neurosurgeon, writes extensively on Aspartame and Alzheimer's. His first book is "Excitotoxins: The Taste That Kills", http://www.russellblaylockmd.com and he has two others. Dr. Woodrow Monte has written a book called "While Science Sleeps: A Sweetener Kills", http:// www.whilesciencesleeps.com, He goes into the methanol in aspartame. He explains how the FDA made a deal with G. D. Searle never to allow the public to see the teratology studies because they showed neural tube defects - autism, spina bifida and cleft palate. From the cradle to the grave aspartame is mass poisoning the public. Those who have given birth after 1984 should fill out the short form on http://www.mpwhi.com, second banner down and send to Dr. Ralph Walton who is conducting a study on aspartame and birth defects. His email address rwalton193@aol.com You can write him direct. There is no criteria for the study except having given birth after 1984.

See some of these physicians in the documentary, "Sweet Misery: A Poisoned World" - http://www.sweetremedy.com

Now read on this excellent article supporting evidence for the aspartame- Alzheimer's link.

Dr. Betty Martini, D.Hum.
Founder, Mission Possible World Health International
9270 River Club Parkway
Duluth, Georgia 30097
770-242-2599
E-Mail: BettyM19@mindspring.com
http://www.wpwhi.com
http://www.wnho.net
http://www.dorway.com

Aspartame Toxicity Center: http://www.holisticmed.com/aspartame


Supporting Evidence for Aspartame-Alzheimer's Link Emerges

By Dr. Joseph Mercola
http://www.mercola.com
June 26, 2014

I just looked and it does not look like Aspartame is banned in most places.  I read that Netherlands, Holland and other European countries banned it but they have not or at least it is approved as they are in the EU now.

I avoid drinking it due to an experience a friend had.  They had a relative they believed had Alzheimers disease.  The relative was drinking aspartame diet beverages because they were diabetic.  Apparently when the diet drinks were removed their memory started to function again. 

Sugar is fine in moderation so I'll stick with it.  I prefer as few additives as possible in food and drinks.

Quote from: Pimander on September 12, 2014, 10:13:23 PM
I just looked and it does not look like Aspartame is banned in most places.  I read that Netherlands, Holland and other European countries banned it but they have not or at least it is approved as they are in the EU now.

That's why I asked, as from what I have seen, it's not banned in any country.
Holland is a region of the Netherlands, although sometimes that name is used instead of Netherlands (we do that in Portugal). :)

QuoteI avoid drinking it due to an experience a friend had.  They had a relative they believed had Alzheimers disease.  The relative was drinking aspartame diet beverages because they were diabetic.  Apparently when the diet drinks were removed their memory started to function again.

I never liked artificial things, and now that I have diabetes I still prefer other sweeteners to Aspartame, as it leaves an after-taste that I do not like.

Quote from: ArMaP on September 12, 2014, 11:39:14 PM
That's why I asked, as from what I have seen, it's not banned in any country.
Holland is a region of the Netherlands, although sometimes that name is used instead of Netherlands (we do that in Portugal). :)

Oh, I meant to delete Holland and replace it with Netherlands but ended up putting both.  I read that Netherlands and Belgium had banned it but they are in the EU where Aspartame is approved so the article was incorrect.  The article also implied that Aspartame was banned in other countries and I didn't check as I don't drink it much myself.